- Title
- Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications
- Creator
- Isbister, Geoffrey K.; Polanski, Robert; Cooper, Joyce M.; Keegan, Michael; Isoardi, Katherine Z.
- Relation
- Clinical Toxicology Vol. 60, Issue 9, p. 1019-1023
- Publisher Link
- http://dx.doi.org/10.1080/15563650.2022.2083631
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2022
- Description
- Objective: Duloxetine is a commonly used antidepressant that is a serotonin and norepinephrine reuptake inhibitor. We aimed to investigate the frequency and severity of clinical effects following duloxetine overdose. Methods: We undertook a retrospective review of duloxetine overdoses (>120 mg) admitted to two tertiary toxicology units between March 2007 and May 2021. Demographic information, details of ingestion (dose, co-ingestants), clinical effects, investigations (ECG parameters including QT interval), complications (coma [GCS < 9], serotonin toxicity, seizures and cardiovascular effects), length of stay [LOS] and intensive care unit [ICU] admission were extracted from a clinical database. Results: There were 241 duloxetine overdoses (>120 mg), median age 37 years (interquartile range [IQR]: 25–48 years) and there were 156 females (65%). The median dose was 735 mg (IQR: 405–1200 mg). In 177 patients, other medications were co-ingested, most commonly alcohol, paracetamol, quetiapine, diazepam, ibuprofen, pregabalin and oxycodone. These patients were more likely to be admitted to ICU (12 [7%] vs. none; p = 0.040), develop coma (16 [9%] vs. none; p = 0.008) and hypotension [systolic BP < 90 mmHg] (15 [8%] vs. one; p = 0.076). Sixty four patients ingested duloxetine alone with a median dose of 840 mg (180–4200 mg). The median LOS, in the duloxetine only group, was 13 h (IQR:8.3–18 h), which was significantly shorter than those taking coingestants, 19 h (IQR:12–31 h; p = 0.004). None of these patients were intubated. Six patients developed moderate serotonin toxicity, without complications and one had a single seizure. Tachycardia occurred in 31 patients (48%) and mild hypertension (systolic BP > 140 mmHg) in 29 (45%). One patient had persistent sympathomimetic toxicity, and one had hypotension after droperidol. Two patients of 63 with an ECG recorded had an abnormal QT: one QT 500 ms, HR 46 bpm, which resolved over 3.5 h and a second with tachycardia (QT 360 ms, HR 119 bpm). None of the 64 patients had an arrhythmia. Conclusion: Duloxetine overdose most commonly caused sympathomimetic effects and serotonin toxicity, consistent with its pharmacology, and did not result in coma, arrhythmias or intensive care admission, when taken alone in overdose.
- Subject
- Duloxetine; selective serotonin reuptake inhibition; norepinephrine reuptake inhibition; antidepressant; drug overdose; toxicity
- Identifier
- http://hdl.handle.net/1959.13/1484741
- Identifier
- uon:51419
- Identifier
- ISSN:1556-3650
- Rights
- This is an Accepted Manuscript of an article published by Taylor & Francis in Clinical Toxicology on 06/06/2022, available at: http://dx.doi.org/10.1080/15563650.2022.2083631
- Language
- eng
- Full Text
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